Cushings Disease Cushings病

Article source: http://www.arktisfun.de/ . 文章来源： http://www.arktisfun.de/ 。 Used with author's permission. 用作者的许可。

As our horses enjoy a longer life and many live well into old age so the number of horses with Cushing increases as its more common in older horses especially ponies.正如我们的马匹享受更长的生命和生活以及许多老年人因此，一些马匹与柯兴增加，因为其较常见于老年人马尤其是小马。 It can however affect all breeds and ages.但是它可以影响到所有品种和年龄。 Cushing is caused by an abnormality of the pituitary gland that is situated at the base of the brain.柯兴所造成的异常垂体是位于该基地的大脑。 This causes it to produce excessive amount of a hormone called cortisone, which is the body's natural steroid hormone.这会导致它产生过多的激素可的松要求，这是身体的天然类固醇激素。

Signs of Cushing柯兴迹象

· Long thick curly coat, which may not shred.龙卷曲的厚外套，不得一丝一毫。

· They may grow their winter coat very early or shred it early as the swelling at the gland puts pressure on the part of the brain that is responsible for seasonal hair loss他们也许种植冬季大衣非常早期或切碎它早在肿胀的腺体施加压力的一部分，这是大脑负责季节性脱发

· An increase risk of laminitis增加风险laminitis

· Excessive drinking and urinating饮酒过量和小便

· Increase appetite增加食欲

· Raised heart rate提高心率

· Muscle wasting肌肉浪费

· In mares their cycle may be abnormal · Mare may not be able to conceive在母马的周期可能会异常海可能无法想象

· Lethargy昏睡

· Weight loss体重减轻

Over a period of time an affected horse will show some or all of the above signs which are listed.经过一段时间受影响的马会显示部分或全部上述迹象列。

Treatment治疗

Within the brain a substance called Dopamine is naturally produce which prevents the over production of hormones.大脑内的一种物质称为多巴胺是自然产生的阻碍生产的荷尔蒙。 There is another natural substance called Serotorum which has the opposite effect and produces to much cortisone.还有一种天然物质称为Serotorum了相反的效果，并产生大量可的松。

Treatment will consist of using a drug which mimics Dopamine the most commonly used one is Pergolide which is given in tablet form or using a drug one of the most promising being Trilostane that will block Serotorum.治疗将包括使用药物，模仿多巴胺最常用的是培高利特是中片的形式或使用药物之一，目前最有前途的Trilostane这将阻止Serotorum 。 Your vet will decide on which cause of treatment will be most suitable for your horse or pony.您的兽医将决定造成的治疗将是最适合你的马或马。 Both types of treatment will bring about the same results, keeping the amount of cortisone produce under control.这两种类型的治疗将带来相同的结果，使大量的可的松生产受到控制。

Management管理

The increase in cortisone in the body is similar to the effect of stress so to manage the condition we need to reduce stress levels as much as possible.增加可的松在体内类似的应力作用，使管理的状况，我们需要减少应力水平尽可能。

· Keep to a strict routine保持严格的例行

· Ensure a comfortable quiet haven for the horse确保一个舒适安静的避风港马

· Avoid turning out with aggressive horses避免转向了积极的马匹

· Keep feed and water easily located保持饲料和水很容易找到

· Clip out and rug in winter剪辑地毯并在冬季

· Groom well to help minimize skin diseases新郎以及帮助尽量减少皮肤疾病

· Keep hooves in good condition保持蹄处于良好状态

· Check for signs of laminitis检查的迹象laminitis

· Minimize contact with new horses尽量减少与新马

· Immunize regularly定期免疫接种

· Have regular dentist checks定期牙科检查

· Feed only high quality easily digestible food饲料只有高品质的容易消化的食物

Treatment and management will be life-long as there is no cure for the condition.治疗和管理将是终身的，因为没有治愈的条件。 I know from my own experience as I had a old pony called Ringo who suffer with Cushing for many years but still live to the grand old age of 35 that horses can live a comfortable life for many years.我知道我自己的经验，我有一个旧小马所谓林戈谁与柯兴遭受多年，但仍活到老大35岁的这匹马能够生活舒适的生活了许多年。 The most serious complication is laminitis and this must be manage carefully最严重的并发症是laminitis ，这必须仔细管理

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